PHARMACY (Lab/Ehrich, Meldrum, Blodgett/2)

1. Write prescriptions for medications, observing proper format and legal requirements.
2. Differentiate between procedures needed for writing prescriptions in Schedules II-VI.
3. Recognize and use abbreviations for writing prescriptions.
4. Convert within and between units of the metric and the apothecary systems of weights and measures.
5. Perform the calculations necessary to prepare drugs for use from stock solutions and from powders.
6. Perform the calculations necessary for administration of drugs on a dose-per-weight basis.
7. Delineate the various types of pharmaceutical preparations used in veterinary medicine.

DOSE RESPONSE (Lab/Ehrich, Meldrum, Blodgett/2)

1. Differentiate between graded and quantal responses.
2. Differentiate between different types of dose response curves, including those using log dose scales and probits.
3. Estimate and ED50's and LD50's by inspection of log dose response curves.
4. Use accumulated data to improve an LD50 determination.
5. Calculate a therapeutic index and discuss the use of dose response curves for drug safety evaluations.
6. Discuss animal variability and what it may mean in terms of dose response curves.

PHARMACOKINETICS (Lab/Wilcke, Ehrich, Blodgett/2)

1. Describe factors which can affect the action of drugs in the body, especially those that affect intensity and duration.
2. Understand concepts of dose rate, peak and trough concentrations, average plasma concentration, volume of distribution, and clearance.
3. Examine the relationship between volume of distribution and drug clearance.
4. Consider steady state in the clinical pharmacokinetics of antiinfective agents in normal and abnormal animals.

DRUG METABOLISM AND DRUG INTERACTIONS (Lab and Review Session/Ehrich, Wilcke/2)

1. Describe the effect of inhibition and induction of hepatic microsomal enzyme on drug duration.
2. Describe the effect of competition for binding sites on drug duration.
3. Review general pharmacokinetic principles.
4. Review basic principles of pharmacology.